abstract：BACKGROUND:The degree of QT prolongation by drug is highly variable and related to risk for polymorphic ventricular tachycardia due to drugs. OBJECTIVE:The purpose of this study was to determine factors that affect the degree of QT prolongation by drugs. METHODS:QT and QTc were measured before and after administratio...

journal_title：Heart rhythm

authors： Kannankeril PJ,Norris KJ,Carter S,Roden DM

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Termination of persistent atrial fibrillation (AF) is a valuable ablation endpoint but is difficult to anticipate. We evaluated whether temporal and spatial indices of AF regularization predict intraprocedural AF termination and outcome. OBJECTIVE:The purpose of this study was to test whether temporospatial...

journal_title：Heart rhythm

authors： Forclaz A,Narayan SM,Scherr D,Linton N,Jadidi AS,Nault I,Rivard L,Miyazaki S,Uldry L,Wright M,Shah AJ,Liu X,Xhaet O,Derval N,Knecht S,Sacher F,Jaïs P,Hocini M,Haïssaguerre M

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) causes negative tracheal pressure (NTP) and is associated with atrial fibrillation (AF). OBJECTIVE:This study aimed to determine the mechanism of atrial electrophysiological changes during tracheal occlusion with or without applied NTP and to evaluate the role of vagal activati...

journal_title：Heart rhythm

authors： Linz D,Schotten U,Neuberger HR,Böhm M,Wirth K

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The R582C mutation is one of many Long-QT Syndrome type 2 (LQT2)-causing mutations localized to the human ether-a-go-go related gene (hERG) channel's S5-P linker subdomain, yet its specific mechanism of dysfunction has not been examined. OBJECTIVE:This study sought to characterize the biophysical properties...

journal_title：Heart rhythm

authors： Fougere RR,Es-Salah-Lamoureux Z,Rezazadeh S,Eldstrom J,Fedida D

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) in the mouse is expressed in the developing cardiac conduction system (CCS). In the sinoatrial node (SAN), HCN4 is the predominant isoform responsible for the funny current. To date, no data are available on HCN4 expression during chicken C...

journal_title：Heart rhythm

authors： Vicente-Steijn R,Passier R,Wisse LJ,Schalij MJ,Poelmann RE,Gittenberger-de Groot AC,Jongbloed MR

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Although risks and life-threatening complications associated with lead extraction are well characterized, practice patterns vary regarding whether procedures are performed in an operating room (OR) or electrophysiology (EP) laboratory with cardiothoracic surgical backup. OBJECTIVE:Our objective was to compa...

journal_title：Heart rhythm

authors： Franceschi F,Dubuc M,Deharo JC,Mancini J,Pagé P,Thibault B,Koutbi L,Prévôt S,Khairy P

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Physicians will increasingly encounter patients who require rhythm management devices but have venous obstructions that prevent conventional access. Alternate access options, such as thoracotomy or transiliac approaches, exist but are associated with greater cost and morbidity. OBJECTIVE:The purpose of this...

journal_title：Heart rhythm

authors： Elayi CS,Allen CL,Leung S,Lusher S,Morales GX,Wiisanen M,Aikat S,Kakavand B,Shah JS,Moliterno DJ,Gurley JC

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Electrocardiographic imaging (ECGI) is a method for noninvasive epicardial electrophysiologic mapping. ECGI previously has been used to characterize the electrophysiologic substrate and electrical synchrony in a very heterogeneous group of patients with varying degrees of coronary disease and ischemic cardio...

journal_title：Heart rhythm

authors： Ghosh S,Silva JN,Canham RM,Bowman TM,Zhang J,Rhee EK,Woodard PK,Rudy Y

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Effective chest compressions during prolonged ventricular fibrillation (VF) have been shown to increase the chances of successful defibrillation to a rhythm associated with a sustainable cardiac output. There is currently no effective method of recording the degree of antegrade coronary artery flow during ch...

journal_title：Heart rhythm

authors： Umapathy K,Foomany FH,Dorian P,Farid T,Sivagangabalan G,Nair K,Masse S,Krishnan S,Nanthakumar K

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The need to add a lead(s) despite subclavian/innominate obstruction is increasing. Subclavian venoplasty may be a good alternative to the commonly employed options; however, there are few reports in the literature, and all are by interventional radiologists. OBJECTIVE:To describe the procedural details, res...

journal_title：Heart rhythm

authors： Worley SJ,Gohn DC,Pulliam RW,Raifsnider MA,Ebersole BI,Tuzi J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Bidirectional ventricular tachycardia (BVT), which is characterized by an alternating beat-to-beat ECG QRS axis, is a rare but intriguing arrhythmia associated with digitalis toxicity, familial catecholaminergic polymorphic ventricular tachycardia (CPVT), and several other conditions that predispose cardiac ...

journal_title：Heart rhythm

authors： Baher AA,Uy M,Xie F,Garfinkel A,Qu Z,Weiss JN

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Ventricular tachycardia (VT) in patients with idiopathic dilated cardiomyopathy often originates from the basal left ventricular myocardium and also can originate from the conduction system. The basal left ventricular myocardium reaches to the base of the aortic sinus cusps. OBJECTIVE:The purpose of this st...

journal_title：Heart rhythm

authors： Yokokawa M,Good E,Crawford T,Jongnarangsin K,Chugh A,Pelosi F Jr,Oral H,Morady F,Bogun F

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common sustained arrhythmia and has a substantial heritable component. Numerous associations between single nucleotide polymorphisms (SNPs) and AF have been described, but few have been replicated. OBJECTIVE:We sought to systematically replicate SNPs that are reported to...

journal_title：Heart rhythm

authors： Sinner MF,Lubitz SA,Pfeufer A,Makino S,Beckmann BM,Lunetta KL,Steinbeck G,Perz S,Rahman R,Sonni A,Greenberg SM,Furie KL,Wichmann HE,Meitinger T,Peters A,Benjamin EJ,Rosand J,Ellinor PT,Kääb S

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Complex fractionated electrograms (CFAEs) detected during substrate mapping for atrial fibrillation (AF) reflect etiologies that are difficult to separate. Without knowledge of local refractoriness and activation sequence, CFAEs may represent rapid localized activity, disorganized wave collisions, or far-fie...

journal_title：Heart rhythm

authors： Narayan SM,Wright M,Derval N,Jadidi A,Forclaz A,Nault I,Miyazaki S,Sacher F,Bordachar P,Clémenty J,Jaïs P,Haïssaguerre M,Hocini M

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Complete circumferential antral ablation may not be necessary for successful pulmonary vein (PV) isolation in patients with paroxysmal atrial fibrillation (AF). OBJECTIVE:We examined the feasibility of a noncircumferential approach limited to segments of the antra required for PV-atrial conduction. METHODS...

journal_title：Heart rhythm

authors： Sy RW,Gula LJ,Leong-Sit P,Klein GJ,Yee R,Krahn AD,Bentley C,Razak S,Skanes AC

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:P wave indices are an intermediate phenotype modulated by atrial conduction and electrophysiology. Their clinical correlates and association with all-cause mortality have received limited scrutiny. OBJECTIVE:To determine the relationship between P wave indices and cardiovascular and all-cause mortality in t...

journal_title：Heart rhythm

authors： Magnani JW,Gorodeski EZ,Johnson VM,Sullivan LM,Hamburg NM,Benjamin EJ,Ellinor PT

更新日期：2011-01-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Heart rhythm

authors： Chen G,Yang X,Kerchner LJ,Salama NR,Alber S,Shusterman V,London B,Salama G

更新日期：2010-12-27 00:00:00

abstract：BACKGROUND:Acute success rates of accessory pathway ablation for Wolff-Parkinson-White (WPW) syndrome can exceed 95%, with rare failures attributed to anatomically complex epicardial connections. Right atrial appendage to right ventricle pathways have been reported, but their left-sided counterparts have only recently ...

journal_title：Heart rhythm

authors： Mah D,Miyake C,Clegg R,Collins KK,Cecchin F,Triedman JK,Mayer J,Walsh EP

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Studies on incidences of sports-related sudden cardiac death (SrSCD) are few and data are needed for the discussion of preparticipation screening for cardiac disease. OBJECTIVE:We sought to chart the incidence and etiology of SrSCD in the young in Denmark (population 5.4 million) and to compare this to the ...

journal_title：Heart rhythm

authors： Holst AG,Winkel BG,Theilade J,Kristensen IB,Thomsen JL,Ottesen GL,Svendsen JH,Haunsø S,Prescott E,Tfelt-Hansen J

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is more prevalent in Caucasians than in persons of other racial/ethnic groups. OBJECTIVE:The purpose of this study was to examine the association between race/ethnicity and new-onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG). METHODS:Data...

journal_title：Heart rhythm

authors： Nazeri A,Razavi M,Elayda MA,Lee VV,Massumi A,Wilson JM

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Recognition of the creation of transmural lesions (TLs) during atrial ablation procedures is important. OBJECTIVE:The purpose of this study was to characterize local unipolar electrograms (UEs) and bipolar electrograms (BEs) recorded from a TL at different catheter orientations. METHODS:In 13 porcines, 125...

journal_title：Heart rhythm

authors： Otomo K,Uno K,Fujiwara H,Isobe M,Iesaka Y

更新日期：2010-09-01 00:00:00

abstract：:Increased cardiac output in response to beta-adrenergic receptor stimulation is achieved by rapid alteration of the activity of cardiac ion channels, pumps, and exchangers. Over the past decade, the discovery of macromolecular complexes, which include the ion channels and pumps and the kinases that control their level...

journal_title：Heart rhythm

authors： Sampson KJ,Kass RS

更新日期：2010-08-01 00:00:00

abstract：:Each heartbeat requires precisely orchestrated action potential propagation through the myocardium, achieved by coordination of about a million ion channels on the surface of each cardiomyocyte. Specific ion channels must occur within discrete subdomains of the sarcolemma to exert their electrophysiological effects wi...

journal_title：Heart rhythm

authors： Smyth JW,Shaw RM

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Phrenic nerve (PN) injury, a known complication of radiofrequency (RF) catheter ablation of atrial fibrillation (AF), has been more commonly reported with balloon-based pulmonary vein isolation. OBJECTIVE:We present a novel approach to locating the PN and predicting patients at higher risk of this complicat...

journal_title：Heart rhythm

authors： Horton R,Di Biase L,Reddy V,Neuzil P,Mohanty P,Sanchez J,Nguyen T,Mohanty S,Gallinghouse GJ,Bailey SM,Zagrodzky JD,Burkhardt JD,Natale A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:As the population ages, recurrent ventricular tachycardia (VT) is increasingly encountered in elderly patients with ischemic heart disease. Radiofrequency catheter ablation is useful for reducing VT therapy in patients with an implantable defibrillator. The utility of radiofrequency catheter ablation in the ...

journal_title：Heart rhythm

authors： Inada K,Roberts-Thomson KC,Seiler J,Steven D,Tedrow UB,Koplan BA,Stevenson WG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Marshall bundles (MBs) are the muscle bundles within the ligament of Marshall. OBJECTIVE:This trial sought to the electrophysiological characteristics of the MB and the anatomical connections between MB and left atrium (LA) in patients with persistent atrial fibrillation (AF). METHODS:We enrolled 72 patien...

journal_title：Heart rhythm

authors： Han S,Joung B,Scanavacca M,Sosa E,Chen PS,Hwang C

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes. OBJECTIVE:The purpose of this study was to undertake a systematic review of the literature with regard to the impact of ablation technique on the outcomes of long-standing persistent AF ...

journal_title：Heart rhythm

authors： Brooks AG,Stiles MK,Laborderie J,Lau DH,Kuklik P,Shipp NJ,Hsu LF,Sanders P

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:We previously showed that omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The mechanisms underlying this effect are unknown. OBJECTIVE:The purpose of this study was to use a genome-wide approach to identify gene expression profiles involved in a new model of AF ...

journal_title：Heart rhythm

authors： Ramadeen A,Laurent G,dos Santos CC,Hu X,Connelly KA,Holub BJ,Mangat I,Dorian P

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The use of radiofrequency identification (RFID) systems is expanding and highlights the need to address electromagnetic interference (EMI) to implantable pacemakers and implantable cardioverter-defibrillators (ICDs). OBJECTIVE:This study sought to examine the electromagnetic compatibility (EMC) between RFID...

journal_title：Heart rhythm

authors： Seidman SJ,Brockman R,Lewis BM,Guag J,Shein MJ,Clement WJ,Kippola J,Digby D,Barber C,Huntwork D

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Nontransvenous (NTV) implantable cardioverter-defibrillator (ICD) systems with pericardial and/or subcutaneous coils are used in select pediatric and congenital heart disease patients who are not candidates for transvenous ICD leads. Outcomes with these hybrid configurations are not well understood. OBJECTI...

journal_title：Heart rhythm

authors： Radbill AE,Triedman JK,Berul CI,Fynn-Thompson F,Atallah J,Alexander ME,Walsh EP,Cecchin F

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The function of the Purkinje system (PS) is to ensure fast and uniform activation of the heart. Although this vital role during sinus rhythm is well understood, this is not the case when shocks are applied to the heart, especially in the case of failed defibrillation. The PS activates differently from the my...

journal_title：Heart rhythm

authors： Deo M,Boyle P,Plank G,Vigmond E

更新日期：2009-12-01 00:00:00

abstract：:The intrinsic cardiac autonomic nervous system (ganglionated plexuses [GP]) plays a significant role in the initiation and maintenance of atrial fibrillation (AF) in both experimental models and AF patients. Left atrial GP, located in epicardial fat pads and the ligament of Marshall, contain afferent neurons from the ...

journal_title：Heart rhythm

authors： Nakagawa H,Scherlag BJ,Patterson E,Ikeda A,Lockwood D,Jackman WM

更新日期：2009-12-01 00:00:00

abstract：:Minimally invasive surgical atrial fibrillation ablation (MISAA) is an emerging alternative to catheter ablation and the full surgical maze procedure for nonpharmacologic treatment of atrial fibrillation. MISAA offers the potential to provide highly effective pulmonary vein isolation, exclusion of the left atrial appe...

journal_title：Heart rhythm

authors： Han FT,Kasirajan V,Wood MA,Ellenbogen KA

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The vein of Marshall (VOM) is a left atrial (LA) vein that contains autonomic innervation and triggers of AF. Its location coincides with areas usually ablated during pulmonary vein (PV) antral isolation (PVAI). OBJECTIVE:This study sought to delineate the safety and ablative effects of ethanol infusion in ...

journal_title：Heart rhythm

authors： Valderrábano M,Liu X,Sasaridis C,Sidhu J,Little S,Khoury DS

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:There is a lack of prospective population-based data regarding sudden death in children. OBJECTIVE:The purpose of this study was to assess the burden of sudden cardiac arrest (SCA) in the pediatric population in a 3-year community-wide study. METHODS:During 2002-2005, all residents of Multnomah County, Ore...

journal_title：Heart rhythm

authors： Chugh SS,Reinier K,Balaji S,Uy-Evanado A,Vickers C,Mariani R,Gunson K,Jui J

更新日期：2009-11-01 00:00:00

abstract：:Founder populations, characterized by a single ancestor affected by long QT syndrome (LQTS) and by a large number of individuals and families who all are related to the ancestor and thereby carry the same disease-causing mutation, represent the ideal human model for studying the role of "modifier genes" in LQTS. This ...

journal_title：Heart rhythm

authors： Brink PA,Schwartz PJ

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The best periprocedural anticoagulation strategy at the time of pulmonary vein isolation (PVI) is not known. Most centers stop administering warfarin (Coumadin) and use bridging with heparin or enoxaparin. OBJECTIVE:The purpose of this study was to evaluate the efficacy and safety of PVI under therapeutic i...

journal_title：Heart rhythm

authors： Hussein AA,Martin DO,Saliba W,Patel D,Karim S,Batal O,Banna M,Williams-Andrews M,Sherman M,Kanj M,Bhargava M,Dresing T,Callahan T,Tchou P,Di Biase L,Beheiry S,Lindsay B,Natale A,Wazni O

更新日期：2009-10-01 00:00:00

abstract：:Understanding of the mechanisms underlying atrial fibrillation (AF) remain limited. However, both persistent and paroxysmal AF likely initiate via the interaction of triggers such as premature atrial beats with 'substrate', that includes static components such as fibrosis and scar, as well as dynamic alterations that ...

journal_title：Heart rhythm

authors： Krummen DE,Narayan SM

更新日期：2009-08-01 00:00:00

abstract：:Safe maneuvering of catheters in and around the ventricles, and ablations for ventricular tachycardia, require knowledge of the anatomy of the cardiac and extracardiac structures. This review emphasises the three-dimensional spatial relationships between the right and left ventricles and highlights the important extra...

journal_title：Heart rhythm

authors： Ho SY

更新日期：2009-08-01 00:00:00

abstract：:The electrophysiologic substrate underlying the development of ventricular tachycardia (VT) in patients with prior infarction has been studied in depth. An increased understanding of its composition and role in the maintenance of reentrant VT has led to the development of substrate modification approaches to ablation ...

journal_title：Heart rhythm

authors： Haqqani HM,Marchlinski FE

更新日期：2009-08-01 00:00:00